Autophagy Controls Nrf2-Mediated Dichotomy in Pressure Overloaded Hearts
Burgeoning evidence has indicated that normal autophagy is required for nuclear factor erythroid 2-related factor (Nrf2)-mediated cardiac protection whereas autophagy inhibition turns on Nrf2-mediated myocardial damage and dysfunction in a setting of pressure overload (PO).However, such a concept remains to be fully established by a careful genetic